Azide-PEG2-MS

• Description :

  Azide-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG2-Ms is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC :

  12352211

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  PROTAC Linkers

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/azide-peg2-ms.html

• Purity :

  97.0

• Solubility :

  10 mM in DMSO

• Smiles :

  [N-]=[N+]=NCCOCCOS(C)(=O)=O

• Molecular Formula :

  C5H11N3O4S

• Molecular Weight :

  209.22

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PEG Linkers

• CAS Number :

  [176520-23-3]