Products for Research Use Only
RegisterLogin

Sintilimab

CAT: 0804-HY-P99048-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P99048-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer[1][2][3][4][5].
CAS Number
2072873-06-2
Product Name Alternative
IBI308
UNSPSC
12352203
Target
PD-1/PD-L1
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sintilimab.html
Purity
99.1
Solubility
H2O
Smiles
[Sintilimab]
Molecular Weight
(144.04 kDa)
References & Citations
[1]Sheridan M Hoy. Sintilimab: First Global Approval Drugs. 2019 Feb;79 (3) :341-346.|[2]Wang J, et al Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. MAbs. 2019 Nov-Dec;11 (8) :1443-1451.|[3]Zhang L, et al. Sintilimab: A Promising Anti-Tumor PD-1 Antibody. Front Oncol. 2020 Nov 26;10:594558.|[4]Yan Q, et al. Prebiotics Modulate Gut Microbiota-mediated T-cell Immunity to Enhance the Inhibitory Effect of Sintilimab in Lewis Lung Adenocarcinoma Model Mice. Anticancer Agents Med Chem. 2023;23 (17) :1966-1973.|[5]Zhang L, et al. Sintilimab for the treatment of non-small cell lung cancer. Biomark Res. 2022 Apr 18;10 (1) :23.|[6]Lou B, et al. Preclinical Characterization of GLS-010 (Zimberelimab), a Novel Fully Human Anti-PD-1 Therapeutic Monoclonal Antibody for Cancer. Front Oncol. 2021 Sep 15;11:736955.
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4°C for 2 years, do not freeze
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

Alternative Products

CatalogName
T35394-01Sintilimab
GTR18291821-01Sintilimab Antibody
MBS1563816-01Research Grade Sintilimab
E55B0455Sintilimab (Reference antibody)
KET-10762Sintilimab ELISA Kit
KBI1632KRIBIOLISA™ Sintilimab (TYVYT) ELISA
ICH5001-50mgSintilimab Biosimilar - Research Grade
A2035-5mgSintilimab (anti-PD-1)
GTR18697745-01Sintilimab Human Monoclonal Antibody

Popular Products