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Rocaglaol

CAT: 0931-TN5639Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-TN5639Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
147059-46-9
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tissue inflammation and neuronal cell death by inhibiting NF-kappa B and AP-1 signaling, resulting in significant neuroprotection in animal models of neurodegeneration. Rocaglaol derivatives can prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limit the apoptosis of cardiomyocytes induced by such agent. Rocaglaol, pyrimidinone and aglaiastatin are potent inhibitors of the growth of K--cells, with IC50 values of 1-10 ng/mL, and induce normal morphology in K--cells at 10-30 ng/mL, they also specifically inhibit protein synthesis.
Smiles
COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)C[C@H]2c1ccccc1
Molecular Formula
C26H26O6
Molecular Weight
434.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
CS-BT-00550Rocaglaol

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