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Serpentine

CAT: 0931-TN4997Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-TN4997Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
18786-24-8
Target
IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activates the phosphorylation of AMPK, which stimulates glucose uptake by C2C12 cells.Serpentine increases the expression of GSK-3β mRNA in muscle tissues, which enhances glucose uptake.Serpentine also increases glucose production and hepatic gluconeogenesis.Serpentine has a significant effect on glucagon secretion and hepatic gluconeogenesis. Serpentine significantly increased glucagon secretion and hepatic gluconeogenesis. In high-fat diet/streptozotocin (HFD/STZ) -induced diabetic mice, Serpentine significantly prolonged insulin hypoglycemia, significantly decreased exogenous insulin use, and inhibited endogenous insulin secretion.
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C(OC)(=O)C=1[C@]2(CC=3C4=C(C=5C(N4)=CC=CC5)C=C[N+]3C[C@@]2([C@H](C)OC1)[H])[H]
Molecular Formula
C21H21N2O3
Molecular Weight
349.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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