Murrangatin

• Target :

  Prostaglandin Receptor|||COX|||IL Receptor|||TNF

• Related Pathways :

  Apoptosis|||Neuroscience|||GPCR/G Protein|||Immunology/Inflammation

• Bioactivity :

  Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277) . Murrangatin also shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. Murrangatin and murracarpin may be a new backbone for developing inhibitors of cyclooxygenase 2, they show chondroprotective activity by downregulation of interleukin-1?, tumor necrosis factor?, prostaglandins E2, and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2.

• Smiles :

  COc1ccc2ccc(=O)oc2c1[C@@H](O)[C@@H](O)C(C)=C

• Molecular Formula :

  C15H16O5

• Molecular Weight :

  276.28

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  37126-91-3