Manassantin A

CAT: 0931-TN4489Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TN4489Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

88497-87-4

Target

TNF, HIF, NF-κB, cAMP, JNK, MAPK, COX, STAT, ERK, Prostaglandin Receptor

Related Pathways

NF-κB, Immunology/Inflammation, Apoptosis, Stem Cells, GPCR/G Protein, Neuroscience, MAPK, JAK/STAT signaling, Chromatin/Epigenetic, Angiogenesis

Bioactivity

Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎoB activation, and improvements in the antioxidant and anti-inflammatory status.Manassantin A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases. Manassantin A inhibits cAMP-induced melanin production by down-regulating the gene expressions of MITF and tyrosinase in melanocytes.

Smiles

[H][C@@]1(O[C@@]([H])([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1

Molecular Formula

C42H52O11

Molecular Weight

732.87

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
MBS5787228	Manassantin A
MBS5801430	Manassantin B

Manassantin A

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