Excisanin A

CAT: 0931-TN4046-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-TN4046-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

78536-37-5

Target

MMP, Integrin, Prostaglandin Receptor, FAK, JNK, GSK-3, Akt, Caspase, PARP, NF-κB, Src, PI3K, Wnt/beta-catenin

Related Pathways

PI3K/Akt/mTOR signaling, GPCR/G Protein, Stem Cells, NF-κB, MAPK, Apoptosis, Immunology/Inflammation, Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Proteases/Proteasome, DNA Damage/DNA Repair, Cytoskeletal Signaling

Bioactivity

ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the cleavage of caspase-3 and the proteolytic degradation of poly (ADP-ribose) polymerase (PARP) .

Smiles

CC1(C)CC[C@H](O)[C@@]2(C)[C@@H]3C[C@H](O)[C@@H]4[C@@H](O)[C@@]3([C@H](O)C[C@H]12)C(=O)C4=C

Molecular Formula

C20H30O5

Molecular Weight

350.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
HY-136699	Excisanin A
CS-BT-00337	Excisanin B
GTR19279627-01	Excisanin D

Excisanin A

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