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Dalbergioidin

CAT: 0931-TN3753Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-TN3753Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
30368-42-4
Target
ROS, PI3K, Akt, Tyrosinase, TGF-beta/Smad
Related Pathways
Immunology/Inflammation, Cytoskeletal Signaling, Proteases/Proteasome, PI3K/Akt/mTOR signaling, Stem Cells
Bioactivity
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway.
Smiles
Oc1ccc(C2COc3cc(O)cc(O)c3C2=O)c(O)c1
Molecular Formula
C15H12O6
Molecular Weight
288.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-N3674Dalbergioidin

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