4,5-Dimethoxycanthin-6-one

• Target:

  PDE|||Cytochromes P450|||Antibacterial

• Related Pathways:

  Microbiology/Virology|||Metabolism

• Purity:

  0.9893

• Bioactivity:

  4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 ?M, Ki: 2.6 ?M) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2.

• Smiles:

  COc1c (OC) c (=O) n2c3ccccc3c3ccnc1c23

• Molecular Formula:

  C16H12N2O3

• Molecular Weight:

  280.28

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  18110-87-7