Kushenol I

• Target :

  TNF|||NOD|||FOXO|||Akt|||p38 MAPK|||IL Receptor|||TLR

• Related Pathways :

  Apoptosis|||MAPK|||Cytoskeletal Signaling|||Immunology/Inflammation|||PI3K/Akt/mTOR signaling|||NF-?B

• Purity :

  0.9984

• Bioactivity :

  Kushenol I is a bioactive compound exhibiting anti-inflammatory, antioxidant, and ulcerative colitis–ameliorating effects, demonstrated in a DSS-induced UC mouse model where oral administration improved colon length, body weight, and disease scores while reducing pro-inflammatory cytokines including IL-1?, IL-6, IL-17, and TNF-?. Kushenol I increase IL-10 expression, inhibited key inflammatory signaling proteins such as AKT, p38 MAPK, PI3K, NLRP3, FOXO1, and TLR4, enhancing intestinal barrier integrity. Kushenol I positively modulate gut microbiota, and elevated splenic T-cell proportions, supporting therapeutic potential in inflammatory bowel disease.

• Smiles :

  C([C@@H](CC=C(C)C)C(C)=C)C1=C2C(=C(OC)C=C1O)C(=O)[C@H](O)[C@H](O2)C3=C(O)C=C(O)C=C3

• Molecular Formula :

  C26H30O7

• Molecular Weight :

  454.51

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  99119-69-4