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Kushenol I

CAT: 0931-TN1842-01Size: 1 mgDry Ice: NoHazardous: No
CAT#: TN1842-01Size: 1 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
99119-69-4
Target
TNF|||NOD|||FOXO|||Akt|||p38 MAPK|||IL Receptor|||TLR
Related Pathways
Apoptosis|||MAPK|||Cytoskeletal Signaling|||Immunology/Inflammation|||PI3K/Akt/mTOR signaling|||NF-?B
Purity
0.9984
Bioactivity
Kushenol I is a bioactive compound exhibiting anti-inflammatory, antioxidant, and ulcerative colitis–ameliorating effects, demonstrated in a DSS-induced UC mouse model where oral administration improved colon length, body weight, and disease scores while reducing pro-inflammatory cytokines including IL-1?, IL-6, IL-17, and TNF-?. Kushenol I increase IL-10 expression, inhibited key inflammatory signaling proteins such as AKT, p38 MAPK, PI3K, NLRP3, FOXO1, and TLR4, enhancing intestinal barrier integrity. Kushenol I positively modulate gut microbiota, and elevated splenic T-cell proportions, supporting therapeutic potential in inflammatory bowel disease.
Smiles
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Molecular Formula
C26H30O7
Molecular Weight
454.51
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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