Kushenol I

• Target:

  TNF|||NOD|||FOXO|||Akt|||p38 MAPK|||IL Receptor|||TLR

• Related Pathways:

  Apoptosis|||MAPK|||Cytoskeletal Signaling|||Immunology/Inflammation|||PI3K/Akt/mTOR signaling|||NF-?B

• Purity:

  0.9984

• Bioactivity:

  Kushenol I is a bioactive compound exhibiting anti-inflammatory, antioxidant, and ulcerative colitis–ameliorating effects, demonstrated in a DSS-induced UC mouse model where oral administration improved colon length, body weight, and disease scores while reducing pro-inflammatory cytokines including IL-1?, IL-6, IL-17, and TNF-?. Kushenol I increase IL-10 expression, inhibited key inflammatory signaling proteins such as AKT, p38 MAPK, PI3K, NLRP3, FOXO1, and TLR4, enhancing intestinal barrier integrity. Kushenol I positively modulate gut microbiota, and elevated splenic T-cell proportions, supporting therapeutic potential in inflammatory bowel disease.

• Smiles:

  C ([C@@H] (CC=C (C) C) C (C) =C) C1=C2C (=C (OC) C=C1O) C (=O) [C@H] (O) [C@H] (O2) C3=C (O) C=C (O) C=C3

• Molecular Formula:

  C26H30O7

• Molecular Weight:

  454.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  99119-69-4