Hyperforin

• Target:

  Calcium Channel|||TRP/TRPV Channel

• Related Pathways:

  Metabolism|||Membrane transporter/Ion channel

• Bioactivity:

  Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ?0.1 ?g/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif.

• Smiles:

  C(C(C)C)(=O)[C@@]12[C@@](CCC=C(C)C)(C)[C@@H](CC=C(C)C)C[C@@](CC=C(C)C)(C1=O)C(=O)C(CC=C(C)C)=C2O

• Molecular Formula:

  C35H52O4

• Molecular Weight:

  536.79

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  11079-53-1