Products for Research Use Only
RegisterLogin

Hellebrigenin

CAT: 0931-TN1728-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-TN1728-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
465-90-7
Target
ERK, JNK, Apoptosis, p38 MAPK, PARP, Caspase, IAP
Related Pathways
Proteases/Proteasome, Apoptosis, MAPK, DNA Damage/DNA Repair, Chromatin/Epigenetic
Purity
0.9998
Bioactivity
Hellebrigenin, as a selective inhibitor of MAPK signaling pathways (ERK, p38, JNK) and XIAP, effectively suppresses Akt expression and phosphorylation. This compound activates endogenous apoptosis pathways (including mitochondrial membrane potential disruption, Caspase family activation, and PARP cleavage) while modulating apoptosis-related protein expression. Hellebrigenin also induces DNA double-strand breaks to activate the ATM pathway, inhibiting tumor cell proliferation and clonogenesis, primarily applied in research of oral squamous cell carcinoma and liver cancer.
Smiles
C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5C=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O)CC2)[H])[H]
Molecular Formula
C24H32O6
Molecular Weight
416.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
TN1729-01Hellebrigenol

Alternative Products

CatalogName
TBW00787Hellebrigenin
MBS5794621Hellebrigenin-3-O-?-glucoside

Popular Products