Pinusolide

CAT: 0931-TL0014-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-TL0014-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

31685-80-0

Target

P38 MAPK, Caspase, Apoptosis, Calcium Channel, ERK, Lipoxygenase, AMPK, PAFR, JNK

Related Pathways

Chromatin/Epigenetic, Membrane transporter/Ion channel, Metabolism, GPCR/G Protein, MAPK, Apoptosis, Proteases/Proteasome, PI3K/Akt/mTOR signaling

Bioactivity

Pinusolide is a platelet activating factor (PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.

Smiles

COC(=O)[C@@]1(C)CCC[C@]2(C)[C@@H](CCC3=CCOC3=O)C(=C)CC[C@@H]12

Molecular Formula

C21H30O4

Molecular Weight

346.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GBA68580-01	Pinusolide

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