Dendrobium phenol

• CAS Number :

  67884-30-4

• Target :

  Glucosidase|||Wnt/beta-catenin

• Related Pathways :

  Stem Cells|||Cytoskeletal Signaling|||Metabolism

• Purity :

  0.9968

• Bioactivity :

  Gigantol is a novel inhibitor of the Wnt/?-catenin pathway. It inhibits Wnt/?-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic ?-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to exert its anti-cataract activity. Gigantol induces growth inhibition and apoptosis of HepG2 cells via the PI3K/Akt/NF-?B signaling pathway.Gigantol also shows ?-glucosidase inhibitory activity.

• Smiles :

  COc1cc(O)cc(CCc2ccc(OC)c(O)c2)c1

• Molecular Formula :

  C16H18O4

• Molecular Weight :

  274.31

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C