Bisdemethoxycurcumin

• Target:

  DNA/RNA Synthesis|||P-gp|||Ferroptosis|||Epigenetic Reader Domain|||Wnt/beta-catenin

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Neuroscience|||Cytoskeletal Signaling|||Membrane transporter/Ion channel|||Stem Cells

• Purity:

  0.9975

• Bioactivity:

  Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1?, 25-dihydroxy vitamin D3 to stimulate amyloid-? clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/?-catenin pathway, and inhibits LPS induction of iNOS expression [3].

• Smiles:

  Oc1ccc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)cc1

• Molecular Formula:

  C19H16O4

• Molecular Weight:

  308.33

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  24939-16-0