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Bisdemethoxycurcumin

CAT: 0931-TL0007-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-TL0007-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
24939-16-0
Target
DNA/RNA Synthesis, P-gp, Ferroptosis, Epigenetic Reader Domain, Wnt/beta-catenin
Related Pathways
Cell Cycle/Checkpoint, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair, Neuroscience, Cytoskeletal Signaling, Membrane transporter/Ion channel, Stem Cells
Purity
0.9975
Bioactivity
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].
Smiles
Oc1ccc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)cc1
Molecular Formula
C19H16O4
Molecular Weight
308.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
TB0087Bisdemethoxycurcumin

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