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NBC 6

CAT: 0931-T9655-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T9655-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2068818-02-8
Target
NOD-like Receptor (NLR), Others
Related Pathways
Immunology/Inflammation, Others
Bioactivity
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with an IC50 of 574 nM. It acts independently of Ca 2+ and inhibits Nigericin-induced inflammasome activation in THP-1 cells, as well as Imiquimod-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) [1].
Smiles
C(Cl)(Cl)(Cl)C1=[NH][B+3](O=C(N)[C-]1C(C)=O)([C-]=2C=CC=CC2)[C-]=3C=CC=CC3
Molecular Formula
C18H16BCl3N2O2
Molecular Weight
409.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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