AMP-945

CAT: 0931-T9576-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T9576-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1393653-34-3

Target

FAK

Related Pathways

Angiogenesis, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors

Purity

0.9976

Bioactivity

AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.

Smiles

COc1cc(ccc1Nc1ncc(c(CCc2ccccc2CC(N)=O)n1)C(F)(F)F)C1CCN(C)CC1

Molecular Formula

C28H32F3N5O2

Molecular Weight

527.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Narmafotinib

Narmafotinib is an orally bioavailable inhibitor of focal adhesion kinase 1 (FAK1; FAK; protein tyrosine kinase 2; PTK2), with potential antineoplastic activity. Upon oral administration, narmafotinib targets and inhibits FAK. This prevents FAK-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in FAK-overexpressing tumor cells. FAK, a non-receptor tyrosine kinase overexpressed in various tumor cell types, is involved in tumor cell survival, proliferation, migration and chemoresistance.

CAS Number	1393653-34-3
PubChem CID	60162119
IUPAC Name	2-[2-[2-[2-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-5-(trifluoromethyl)pyrimidin-4-yl]ethyl]phenyl]acetamide
Molecular Formula	C28H32F3N5O2
Molecular Weight	527.6
XLogP	4.6
Topological Polar Surface Area	93.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Heavy Atom Count	38
Formal Charge	0
Complexity	748

SMILES

CN1CCC(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)CCC4=CC=CC=C4CC(=O)N)C(F)(F)F)OC

InChI

InChI=1S/C28H32F3N5O2/c1-36-13-11-19(12-14-36)21-8-10-24(25(15-21)38-2)35-27-33-17-22(28(29,30)31)23(34-27)9-7-18-5-3-4-6-20(18)16-26(32)37/h3-6,8,10,15,17,19H,7,9,11-14,16H2,1-2H3,(H2,32,37)(H,33,34,35)

InChIKey

AWJVIOYPZZZYAX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1393653-34-3

CID: 60162119

Formula: C28H32F3N5O2

MW: 527.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	527.6
XLogP3	4.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	9
Exact Mass	527.25080977
Monoisotopic Mass	527.25080977
Topological Polar Surface Area	93.4 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	748
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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AMP-945

Chemical Information

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