MRTX1133

• Target:

  Ras|||Kras

• Related Pathways:

  MAPK|||GPCR/G Protein

• Purity:

  0.996

• Bioactivity:

  MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.

• Smiles:

  Oc1cc (-c2ncc3c (nc (OC[C@@]45CCCN4C[C@H] (F) C5) nc3c2F) N2C[C@@H]3CC[C@H] (C2) N3) c2c (C#C) c (F) ccc2c1

• Molecular Formula:

  C33H31F3N6O2

• Molecular Weight:

  600.63

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2621928-55-8