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MRTX1133

CAT: 0931-T9303-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T9303-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2621928-55-8
Target
Ras, Kras
Related Pathways
MAPK, GPCR/G Protein
Purity
0.996
Bioactivity
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors.
Smiles
Oc1cc(-c2ncc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3c2F)N2C[C@@H]3CC[C@H](C2)N3)c2c(C#C)c(F)ccc2c1
Molecular Formula
C33H31F3N6O2
Molecular Weight
600.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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