MPP+ iodide

• Target :

  Autophagy|||Mitochondrial Metabolism

• Related Pathways :

  Autophagy|||Metabolism

• Purity :

  0.9996

• Bioactivity :

  MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

• Smiles :

  [I-].C=1C=CC(=CC1)C=2C=C[N+](=CC2)C

• Molecular Formula :

  C12H12IN

• Molecular Weight :

  297.13

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  36913-39-0