MPP+ iodide

• Target:

  Autophagy|||Mitochondrial Metabolism

• Related Pathways:

  Autophagy|||Metabolism

• Purity:

  0.9996

• Bioactivity:

  MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

• Smiles:

  [I-].C=1C=CC (=CC1) C=2C=C[N+] (=CC2) C

• Molecular Formula:

  C12H12IN

• Molecular Weight:

  297.13

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  36913-39-0