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KA2507

CAT: 0931-T9148-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T9148-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1636894-46-6
Target
HDAC
Related Pathways
Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9914
Bioactivity
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
Smiles
ONC(=O)c1ccc(CN(c2cnccn2)c2cnccn2)cc1
Molecular Formula
C16H14N6O2
Molecular Weight
322.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

KA2507

HDAC6 Inhibitor KA2507 is an orally bioavailable inhibitor of histone deacetylase (HDAC) type 6 (HDAC6; HDAC-6), with potential antineoplastic activity. Upon administration, KA2507 targets, binds to and inhibits the activity of HDAC6. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. Specifically, inhibition of HDAC6 prevents STAT3 activity, which leads to a reduction in programmed death-1 (PD-1) expression. Eventually, this results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC6. HDAC6, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins.

CAS Number1636894-46-6
PubChem CID117703516
IUPAC Name4-[[di(pyrazin-2-yl)amino]methyl]-N-hydroxybenzamide
Molecular FormulaC16H14N6O2
Molecular Weight322.32
XLogP0.3
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity384
SMILES
C1=CC(=CC=C1CN(C2=NC=CN=C2)C3=NC=CN=C3)C(=O)NO
InChI
InChI=1S/C16H14N6O2/c23-16(21-24)13-3-1-12(2-4-13)11-22(14-9-17-5-7-19-14)15-10-18-6-8-20-15/h1-10,24H,11H2,(H,21,23)
InChIKey
LXHMTDHBMRZSHJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of KA2507
CAS: 1636894-46-6
CID: 117703516
Formula: C16H14N6O2
MW: 322.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight322.32
XLogP30.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass322.11782371
Monoisotopic Mass322.11782371
Topological Polar Surface Area104 Ų
Heavy Atom Count24
Formal Charge0
Complexity384
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4133-1KA2507
GTR19215558KA2507 monohydrochloride
HY-138799AKA2507 (monohydrochloride)
A24072-5KA2507 5mg
A24072-50KA2507 50mg
A24072-10KA2507 10mg
A24072-100KA2507 100mg

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