BI-0115

CAT: 0931-MF-0095883-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0095883-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
4929-23-1
Target
Lipoxygenase
Related Pathways
Metabolism
Purity
0.9969
Bioactivity
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
Smiles
CCCN1c2cccnc2Nc2cc(Cl)ccc2C1=O
Molecular Formula
C15H14ClN3O
Molecular Weight
287.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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