BI-0115

• Target:

  Lipoxygenase

• Related Pathways:

  Metabolism

• Purity:

  0.9969

• Bioactivity:

  BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.

• Smiles:

  CCCN1c2cccnc2Nc2cc (Cl) ccc2C1=O

• Molecular Formula:

  C15H14ClN3O

• Molecular Weight:

  287.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  4929-23-1