AES-350

CAT: 0931-T9041-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T9041-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
847249-57-4
Target
Apoptosis|||HDAC
Related Pathways
Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Apoptosis
Purity
0.992
Bioactivity
AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 ?M and 0.035 ?M, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 ?M, 0.245 ?M, and >1 ?M, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
Smiles
CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO
Molecular Formula
C18H20N2O3
Molecular Weight
312.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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