AES-350

• Target :

  Apoptosis|||HDAC

• Related Pathways :

  Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Apoptosis

• Purity :

  0.992

• Bioactivity :

  AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 ?M and 0.035 ?M, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 ?M, 0.245 ?M, and >1 ?M, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.

• Smiles :

  CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)NO

• Molecular Formula :

  C18H20N2O3

• Molecular Weight :

  312.36

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  847249-57-4