AES-350

• Target:

  Apoptosis|||HDAC

• Related Pathways:

  Chromatin/Epigenetic|||DNA Damage/DNA Repair|||Apoptosis

• Purity:

  0.992

• Bioactivity:

  AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and Ki of 0.0244 ?M and 0.035 ?M, respectively), also exhibiting activity against HDAC-3, -8, and -11 in an enzymatic assay with IC50 values of 0.187 ?M, 0.245 ?M, and >1 ?M, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.

• Smiles:

  CC (C) (C) c1ccc (cc1) C (=O) Nc1ccc (cc1) C (=O) NO

• Molecular Formula:

  C18H20N2O3

• Molecular Weight:

  312.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  847249-57-4