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GW779439X

CAT: 0931-T8866-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T8866-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
551919-98-3
Target
Apoptosis, Aurora Kinase, Antibacterial, CDK
Related Pathways
Apoptosis, Chromatin/Epigenetic, Cell Cycle/Checkpoint, Microbiology/Virology
Purity
0.9923
Bioactivity
GW779439X is a pyrazolopyridazine compound that inhibits the S. aureus kinase Stk1 and Aurora kinase A (AURKA) . It restores the efficacy of β-lactam antibiotics against methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) S. aureus, often re-sensitizing resistant strains. This antibacterial potentiation is achieved through the induction of apoptosis via caspase-3/7 pathway activation.
Smiles
CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F
Molecular Formula
C22H21F3N8
Molecular Weight
454.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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GTR19167058-01GW779439X
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A22083-100GW779439X 100mg
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A22083-25GW779439X 25mg
A22083-2GW779439X 2mg

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