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CAN508

CAT: 0931-T8796-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T8796-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
140651-18-9
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Purity
>99.99%
Bioactivity
CAN508 is a potent ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It also competitively inhibits Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 μM and 20 μM, respectively. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. [Antitumor activity.]
Smiles
Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1
Molecular Formula
C9H10N6O
Molecular Weight
218.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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