Zingerone

• Description:

  Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor[3] properties[1]. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways[2]. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells[3].

• Product Name Alternative:

  Vanillylacetone; Gingerone

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  NF-κB

• Type:

  Natural Products

• Related Pathways:

  NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Zingerone.html

• Concentration:

  10mM

• Purity:

  99.79

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC1=C (O) C=CC (CCC (C) =O) =C1

• Molecular Formula:

  C11H14O3

• Molecular Weight:

  194.23

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Ahmad B, et al. A Review on Pharmacological Properties of Zingerone (4- (4-Hydroxy-3-methoxyphenyl) -2-butanone) . ScientificWorldJournal. 2015;2015:816364.|[2]Ahmad B, et al. Zingerone (4- (4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation. Saudi Pharm J. 2018 Dec;26 (8) :1137-1145.|[3]Choi JS, et al. Zingerone Suppresses Tumor Development through Decreasing Cyclin D1 Expression and Inducing Mitotic Arrest. Int J Mol Sci. 2018 Sep 19;19 (9) .

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  122-48-5