Apcin

CAT: 0931-T8561-01Size: 1 mgDry Ice: NoHazardous: No

CAT#:0931-T8561-01Size:1 mg

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PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

CAS Number

300815-04-7

Target

APC/C

Related Pathways

Cell Cycle/Checkpoint

Purity

0.9674

Bioactivity

Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C (Cdc20) ) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe.

Smiles

Cc1ncc(n1CCC(=O)NC(Nc1ccccc1)C(Cl)(Cl)Cl)[N+]([O-])=O

Molecular Formula

C13H14Cl3N7O4

Molecular Weight

438.65

Shipping Conditions

Cool pack

Storage Temperature

-20°C