2-Bromo-4'-hydroxyacetophenone

CAT: 0931-T7084Size: 1 gDry Ice: NoHazardous: No
CAT#:0931-T7084Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2491-38-5
Target
Phosphatase
Related Pathways
Metabolism
Purity
0.9907
Bioactivity
2-Bromo-4'-hydroxyacetophenone (PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SHP-1 (?SH2) ) with a Ki value of 43 ?M and PTP1B with a Ki value of 42 ?M [1]. SHP-1 and PTP1B both have known roles in regulating insulin signaling as well as myeloid and lymphoid cell differentiation, making inhibitors of these phosphatases of interest in diabetes, cancer, allergy, and inflammation research [2].
Smiles
OC1=CC=C(C=C1)C(=O)CBr
Molecular Formula
C8H7BrO2
Molecular Weight
215.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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