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Voxtalisib

CAT: 0931-T7014-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T7014-02Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
934493-76-2
Target
PI3K, DNA-PK, mTOR
Related Pathways
DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Purity
0.9969
Bioactivity
Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
Smiles
CCn1c2nc(N)nc(C)c2cc(-c2cc[nH]n2)c1=O
Molecular Formula
C13H14N6O
Molecular Weight
270.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Voxtalisib

2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)-7-pyrido[2,3-d]pyrimidinone is a pyrazolopyridine.

CAS Number934493-76-2
PubChem CID16123056
IUPAC Name2-amino-8-ethyl-4-methyl-6-(1H-pyrazol-5-yl)pyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC13H14N6O
Molecular Weight270.29
XLogP0.5
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity425
SMILES
CCN1C2=NC(=NC(=C2C=C(C1=O)C3=CC=NN3)C)N
InChI
InChI=1S/C13H14N6O/c1-3-19-11-8(7(2)16-13(14)17-11)6-9(12(19)20)10-4-5-15-18-10/h4-6H,3H2,1-2H3,(H,15,18)(H2,14,16,17)
InChIKey
RGHYDLZMTYDBDT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Voxtalisib
CAS: 934493-76-2
CID: 16123056
Formula: C13H14N6O
MW: 270.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight270.29
XLogP30.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass270.12290909
Monoisotopic Mass270.12290909
Topological Polar Surface Area101 Ų
Heavy Atom Count20
Formal Charge0
Complexity425
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-15900-01Voxtalisib
HY-15900R-01Voxtalisib (Standard)
206941Voxtalisib-Analog
C12841-25mgVoxtalisib (XL765)
C16366-50mgVoxtalisib (XL765) Analogue
MBS579530Voxtalisib (XL765, SAR245409)
MBS386376-01SAR245409 (XL765, Voxtalisib)
A16276-2SAR245409 (XL765, Voxtalisib) 2mg
A16276-100SAR245409 (XL765, Voxtalisib) 100mg

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