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Schisandrol B

CAT: 0931-T6S1917-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T6S1917-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
58546-54-6
Target
Autophagy, Reactive Oxygen Species, Cytochromes P450, ROS
Related Pathways
Autophagy, Metabolism, Immunology/Inflammation, NF-κB
Purity
0.9995
Bioactivity
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl (4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.
Smiles
COc1cc2CC(C)(O)C(C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC
Molecular Formula
C23H28O7
Molecular Weight
416.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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