Schisandrol B

• CAS Number :

  58546-54-6

• Target :

  Autophagy|||Reactive Oxygen Species|||Cytochromes P450|||ROS

• Related Pathways :

  Autophagy|||Metabolism|||Immunology/Inflammation|||NF-?B

• Purity :

  0.9995

• Bioactivity :

  1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-?B and MAPKs signaling pathways. 2. Schisandrol B has anti-inflammatory property, potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-? and NO through the down-regulation of RIP2 and NF-?B activation. 3. Schisandrol B induces marked protective effects against hepatic and renal injury induced by CCl (4) exposure through differential regulation of the MAPK signal transduction pathway. 4. Schisandrol B significantly inhibits cell proliferation in a dose-dependent manner, due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation.

• Smiles :

  COc1cc2CC(C)(O)C(C)Cc3cc4OCOc4c(OC)c3-c2c(OC)c1OC

• Molecular Formula :

  C23H28O7

• Molecular Weight :

  416.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C