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Oroxylin A

CAT: 0931-T6S1315-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T6S1315-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
480-11-5
Target
Autophagy, HIF/HIF Prolyl-Hydroxylase, Virus Protease
Related Pathways
Microbiology/Virology, Autophagy, Chromatin/Epigenetic, Metabolism
Purity
0.9967
Bioactivity
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.
Smiles
COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1
Molecular Formula
C16H12O5
Molecular Weight
284.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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