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SU6656

CAT: 0931-T6997-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T6997-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
330161-87-0
Target
Akt, FAK, Src
Related Pathways
PI3K/Akt/mTOR signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Purity
0.9873
Bioactivity
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Smiles
C(=C1C=2C(NC1=O)=CC=C(S(N(C)C)(=O)=O)C2)C3=CC4=C(N3)CCCC4
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2,3-dihydro-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-1H-Indole-5-sulfonamide

SU6656 is a member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase. It has a role as an antineoplastic agent, an Aurora kinase inhibitor and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a sulfonamide and a member of oxindoles.

CAS Number330161-87-0
PubChem CID5309
IUPAC NameN,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indole-5-sulfonamide
Molecular FormulaC19H21N3O3S
Molecular Weight371.5
XLogP2.1
Topological Polar Surface Area90.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity697
SMILES
CN(C)S(=O)(=O)C1=CC2=C(C=C1)NC(=O)C2=CC3=CC4=C(N3)CCCC4
InChI
InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)
InChIKey
LOGJQOUIVKBFGH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2,3-dihydro-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-1H-Indole-5-sulfonamide
CAS: 330161-87-0
CID: 5309
Formula: C19H21N3O3S
MW: 371.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight371.5
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass371.13036271
Monoisotopic Mass371.13036271
Topological Polar Surface Area90.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP03471-01SU6656
A15518-5SU6656 5mg
A15518-100SU6656 100mg
A15518-25SU6656 25mg
A15518-2SU6656 2mg
A15518-1SU6656 1mg

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