Picropodophyllin

• Target:

  Apoptosis|||IGF-1R

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Apoptosis

• Purity:

  0.9983

• Bioactivity:

  Picropodophyllin (Picropodophyllin (PPP) ) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM) . Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT) .

• Smiles:

  [H][C@]12COC(=O)[C@@]1([H])[C@H](c1cc(OC)c(OC)c(OC)c1)c1cc3OCOc3cc1[C@@H]2O

• Molecular Formula:

  C22H22O8

• Molecular Weight:

  414.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  477-47-4