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PD0166285

CAT: 0931-T6931-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T6931-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
185039-89-8
Target
Apoptosis, Chk, Wee1
Related Pathways
Cell Cycle/Checkpoint, Apoptosis
Purity
0.9959
Bioactivity
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.
Smiles
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
Molecular Formula
C26H27Cl2N5O2
Molecular Weight
512.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one
CAS Number185039-89-8
PubChem CID5311382
IUPAC Name6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC26H27Cl2N5O2
Molecular Weight512.4
XLogP5.6
Topological Polar Surface Area70.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity719
SMILES
CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl
InChI
InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31)
InChIKey
IFPPYSWJNWHOLQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one
CAS: 185039-89-8
CID: 5311382
Formula: C26H27Cl2N5O2
MW: 512.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight512.4
XLogP35.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass511.1541805
Monoisotopic Mass511.1541805
Topological Polar Surface Area70.6 Ų
Heavy Atom Count35
Formal Charge0
Complexity719
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3841225-01PD0166285
A15863-50PD0166285 50mg
A15863-100PD0166285 100mg

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