AZD8186

CAT: 0931-T6773-01Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0931-T6773-01Size:2 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1627494-13-6

Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Purity

0.9991

Bioactivity

AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM) .

Smiles

C[C@@H](Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C

Molecular Formula

C24H25F2N3O4

Molecular Weight

457.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Azd-8186

AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery).

CAS Number	1627494-13-6
PubChem CID	52913813
IUPAC Name	8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide
Molecular Formula	C24H25F2N3O4
Molecular Weight	457.5
XLogP	3
Topological Polar Surface Area	71.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Heavy Atom Count	33
Formal Charge	0
Complexity	748

SMILES

C[C@H](C1=CC(=CC2=C1OC(=CC2=O)N3CCOCC3)C(=O)N(C)C)NC4=CC(=CC(=C4)F)F

InChI

InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

InChIKey

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Chemical Structure

2D Structure

CAS: 1627494-13-6

CID: 52913813

Formula: C24H25F2N3O4

MW: 457.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	457.5
XLogP3	3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	457.18131261
Monoisotopic Mass	457.18131261
Topological Polar Surface Area	71.1 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	748
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
MBS384287-01	AZD8186
A15759-25	AZD8186 25mg
A15759-5	AZD8186 5mg
A14164-10	AZD8186 10mg
A15759-100	AZD8186 100mg
HY-108958	(Rac) -AZD8186
A15759-500	AZD8186 500mg
A15759-50	AZD8186 50mg

AZD8186

Chemical Information

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