Bafilomycin A1

CAT: 0931-MF-0096039-01Size: 160 µL - 1 mM (in DMSO)Dry Ice: NoHazardous: No
CAT#:0931-MF-0096039-01Size:160 µL - 1 mM (in DMSO)
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
88899-55-2
Target
Autophagy|||Apoptosis|||Proton pump|||Antibiotic|||Antibacterial
Related Pathways
Microbiology/Virology|||Autophagy|||Membrane transporter/Ion channel|||Apoptosis
Purity
0.9936
Bioactivity
Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.
Smiles
[H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
Molecular Formula
C35H58O9
Molecular Weight
622.83
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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