Bafilomycin A1

• Target:

  Autophagy|||Apoptosis|||Proton pump|||Antibiotic|||Antibacterial

• Related Pathways:

  Microbiology/Virology|||Autophagy|||Membrane transporter/Ion channel|||Apoptosis

• Purity:

  0.9936

• Bioactivity:

  Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase inhibitor (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis.

• Smiles:

  [H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C

• Molecular Formula:

  C35H58O9

• Molecular Weight:

  622.83

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  88899-55-2