NSC697923

CAT: 0931-T6611-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T6611-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

343351-67-7

Target

Apoptosis, E1/E2/E3 Enzyme

Related Pathways

Apoptosis, Ubiquitination

Purity

0.9984

Bioactivity

NSC-697923 (2-[ (4-methylphenyl) sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.

Smiles

Cc1ccc(cc1)S(=O)(=O)c1ccc(o1)[N+]([O-])=O

Molecular Formula

C11H9NO5S

Molecular Weight

267.26

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
A8813-10	NSC697923

NSC697923

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