NSC697923

• Target :

  Apoptosis|||E1/E2/E3 Enzyme

• Related Pathways :

  Apoptosis|||Ubiquitination

• Purity :

  0.9984

• Bioactivity :

  NSC-697923 (2-[ (4-methylphenyl) sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-?B signaling, further contributing to its antitumor activity.

• Smiles :

  Cc1ccc(cc1)S(=O)(=O)c1ccc(o1)[N+]([O-])=O

• Molecular Formula :

  C11H9NO5S

• Molecular Weight :

  267.26

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  343351-67-7