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Naratriptan hydrochloride

CAT: 0931-T6602-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T6602-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
143388-64-1
Target
5-HT Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Purity
0.9993
Bioactivity
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.
Smiles
Cl.CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1
Molecular Formula
C17H25N3O2S·HCl
Molecular Weight
371.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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