MPEP

CAT: 0931-T6598-05Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0931-T6598-05Size:200 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

96206-92-7

Target

GluR

Related Pathways

Neuroscience

Purity

0.9954

Bioactivity

MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.

Smiles

Cl.Cc1cccc(n1)C#Cc1ccccc1

Molecular Formula

C14H11N

Molecular Weight

193.24

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Mpep

2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as an anxiolytic drug and a metabotropic glutamate receptor antagonist. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.

CAS Number	96206-92-7
PubChem CID	3025961
IUPAC Name	2-methyl-6-(2-phenylethynyl)pyridine
Molecular Formula	C14H11N
Molecular Weight	193.24
XLogP	3.3
Topological Polar Surface Area	12.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Heavy Atom Count	15
Formal Charge	0
Complexity	251

SMILES

CC1=NC(=CC=C1)C#CC2=CC=CC=C2

InChI

InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3

InChIKey

NEWKHUASLBMWRE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 96206-92-7

CID: 3025961

Formula: C14H11N

MW: 193.24

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	193.24
XLogP3	3.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	2
Exact Mass	193.089149355
Monoisotopic Mass	193.089149355
Topological Polar Surface Area	12.9 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	251
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
B1628-10	MPEP
HY-14609-01	MPEP (Hydrochloride)
456629-01	MPEP Hydrochloride
abx282936-01	MPEP HCl

MPEP

Chemical Information

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