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Dofetilide

CAT: 0931-T6476-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T6476-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
115256-11-6
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9906
Bioactivity
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
Smiles
N(S(C)(=O)=O)C1=CC=C(CCN(CCOC2=CC=C(NS(C)(=O)=O)C=C2)C)C=C1
Molecular Formula
C19H27N3O5S2
Molecular Weight
441.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Dofetilide

Dofetilide is a tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug. It has a role as an anti-arrhythmia drug and a potassium channel blocker. It is a sulfonamide, an aromatic ether and a tertiary amino compound.

CAS Number115256-11-6
PubChem CID71329
IUPAC NameN-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
Molecular FormulaC19H27N3O5S2
Molecular Weight441.6
XLogP1.8
Topological Polar Surface Area122
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Heavy Atom Count29
Formal Charge0
Complexity672
SMILES
CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
InChI
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChIKey
IXTMWRCNAAVVAI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dofetilide
CAS: 115256-11-6
CID: 71329
Formula: C19H27N3O5S2
MW: 441.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.6
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Exact Mass441.13921332
Monoisotopic Mass441.13921332
Topological Polar Surface Area122 Ų
Heavy Atom Count29
Formal Charge0
Complexity672
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
3757/25Dofetilide

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