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Dofetilide

CAT: 0931-T6476-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T6476-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
115256-11-6
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9906
Bioactivity
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
Smiles
N(S(C)(=O)=O)C1=CC=C(CCN(CCOC2=CC=C(NS(C)(=O)=O)C=C2)C)C=C1
Molecular Formula
C19H27N3O5S2
Molecular Weight
441.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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