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Caffeic Acid Phenethyl Ester

CAT: 0931-T6429-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T6429-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
104594-70-9
Target
Apoptosis, NF-κB
Related Pathways
Apoptosis, NF-κB
Purity
0.9993
Bioactivity
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF) -1alpha and subsequent induction of heme oxygenase-1 (HO-1) .
Smiles
Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O
Molecular Formula
C17H16O4
Molecular Weight
284.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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