Caffeic Acid Phenethyl Ester

• Target:

  Apoptosis|||NF-?B

• Related Pathways:

  Apoptosis|||NF-?B

• Purity:

  0.9993

• Bioactivity:

  Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF) -1alpha and subsequent induction of heme oxygenase-1 (HO-1) .

• Smiles:

  Oc1ccc (\C=C\C (=O) OCCc2ccccc2) cc1O

• Molecular Formula:

  C17H16O4

• Molecular Weight:

  284.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  104594-70-9