Caffeic Acid Phenethyl Ester

• Target :

  Apoptosis|||NF-?B

• Related Pathways :

  Apoptosis|||NF-?B

• Purity :

  0.9993

• Bioactivity :

  Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF) -1alpha and subsequent induction of heme oxygenase-1 (HO-1) .

• Smiles :

  Oc1ccc(\C=C\C(=O)OCCc2ccccc2)cc1O

• Molecular Formula :

  C17H16O4

• Molecular Weight :

  284.31

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  104594-70-9