ODN 2088

CAT: 0931-T64278-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T64278-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1146541-45-8
Target
TLR|||COX|||IL Receptor
Related Pathways
Neuroscience|||Immunology/Inflammation
Bioactivity
ODN 2088 is an effective Toll-like receptor inhibitor exhibiting significant inhibitory activity against TLR3, TLR7, and TLR9 without cytotoxicity. It reduces IFN-? and IL-6 release by blocking associated innate immune signaling pathways. In vitro experiments demonstrated that ODN 2088 (0.01–10 ?M, 48 hours) showed minimal inhibition of IL-6 release induced by CpG-ODN 2006 (100 nM), but markedly suppressed IL-6 secretion from human peripheral blood mononuclear cells stimulated by imiquimod (5 ?g/mL) . This demonstrates its differential regulatory potential across distinct TLR activation pathways.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS5779883AZ-2088
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MBS5820657FITC-labeled ODN 2088 sodium
HY-150738ABiotin-labeled ODN 2088 (sodium)
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