IKK?-IN-1

• Target :

  Others|||I?B/IKK

• Related Pathways :

  NF-?B|||Others

• Bioactivity :

  IKK?-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-?) with an IC50 of 0.20 ?M. It reduces the inhibition of PGE2 and TNF-? production in murine macrophages and protects mice from infection shock-induced death.

• Smiles :

  O=C\1N(C(=O)S/C1=C\C2=CC=C(OC3=CC=C(C#N)C=C3)C=C2)C4=CC=C(OCCCN5CCN(C)CC5)C=C4

• Molecular Formula :

  C31H30N4O4S

• Molecular Weight :

  554.66

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2410423-31-1