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SHR902275

CAT: 0931-T63542-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63542-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2695506-82-0
Target
Raf, Others
Related Pathways
Others, MAPK
Bioactivity
SHR902275 is a selective, potent, orally active RAF inhibitor targeting RAS mutant cancers, acting on cRAF (IC50: 1.6 nM), bRAFwt (IC50: 10 nM), and bRAFV600E (IC50: 5.7 nM) . SHR902275 exhibits cell growth inhibitory effects in H358 cells (GI50: 1.5 nM), A375 cells (GI50: 0.17 nM), Calu6 cells (GI50: 0.4 nM), and SK-MEL2 cells (GI50: 0.32 nM) .
Smiles
O=C1CC2(OC=3C(N1)=CC=C(C3)C4=CC(NC(=O)C5=CC(C(F)(F)F)=CN=N5)=CC=C4C)CCOCC2
Molecular Formula
C26H23F3N4O4
Molecular Weight
512.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19185104-01SHR902275

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