BI-1622

CAT: 0931-T63492-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T63492-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2681392-19-6

Target

Others, BTK, PI4K, JAK, EGFR, Raf, CDK, Tyrosine Kinases

Related Pathways

Chromatin/Epigenetic, JAK/STAT signaling, MAPK, Stem Cells, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Others, Angiogenesis

Bioactivity

BI-1622 is a highly selective, orally active HER2 (ERBB2) inhibitor (IC50: 7 nM) . BI-1622 is >25-fold selective for EGFR. In a mouse model of transplanted tumors transfected with H2170 and PC9 cells, BI-1622 exhibited high in vivo antitumor effects with good drug metabolism and pharmacokinetic properties.

Smiles

N(C=1C2=C(C=NC(=N2)N3CCN(C(C=C)=O)CC3)N=CN1)C4=CC(C)=C(OC5=CC=6N(C=C5)N=CN6)C=C4

Molecular Formula

C26H24N10O2

Molecular Weight

508.53

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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BA3815-10	BI-1622
108200 100	Hyamine 1622
MBS5811133	IMD-1622
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01365 05000	Hyamine 1622 Solution 0.004M
844460-01	Hyamine 1622 Soln. 0.004m
B2798-500	BI
S0099	Scavenger Receptor BI (SR-BI)
MBS131573	BI-9564 (BI 9564; BI9564)

BI-1622

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