BI-1622

• CAS Number :

  2681392-19-6

• Target :

  Others|||BTK|||PI4K|||JAK|||EGFR|||Raf|||CDK|||Tyrosine Kinases

• Related Pathways :

  Chromatin/Epigenetic|||JAK/STAT signaling|||MAPK|||Stem Cells|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint|||Others|||Angiogenesis

• Bioactivity :

  BI-1622 is a highly selective, orally active HER2 (ERBB2) inhibitor (IC50: 7 nM) . BI-1622 is >25-fold selective for EGFR. In a mouse model of transplanted tumors transfected with H2170 and PC9 cells, BI-1622 exhibited high in vivo antitumor effects with good drug metabolism and pharmacokinetic properties.

• Smiles :

  N(C=1C2=C(C=NC(=N2)N3CCN(C(C=C)=O)CC3)N=CN1)C4=CC(C)=C(OC5=CC=6N(C=C5)N=CN6)C=C4

• Molecular Formula :

  C26H24N10O2

• Molecular Weight :

  508.53

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C