Products for Research Use Only
RegisterLogin

MS8511

CAT: 0931-T63351-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T63351-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2866408-21-9
Target
Histone Methyltransferase, Others
Related Pathways
Others, Chromatin/Epigenetic
Bioactivity
MS8511, a selective covalent irreversible inhibitor of G9a/GLP, targets a cysteine residue at the substrate binding site, displaying IC50 values of 100 nM (G9a) and 140 nM (GLP), alongside Kd values of 44 nM (G9a) and 46 nM (GLP) . This compound effectively reduces cellular H3K9me2 levels and boosts antiproliferation activity, making it applicable in cancer research involving brain, breast, ovarian, lung, bladder, melanoma, and colorectal cancers, as well as studies on Alzheimer's disease (AD), sickle cell disease, and Prader−Willi syndrome (PWS) [1].
Smiles
N(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=C(NC(C=C)=O)C1)C4CCN(C(C)C)CC4
Molecular Formula
C28H41N5O3
Molecular Weight
495.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T209485-01MS8535
T74675-01MS8815

Alternative Products

CatalogName
HY-150510-01MS8511
MBS5806021MS8511 HCl
BUP23137MS8511 hydrochloride
HY-150510A-01MS8511 (hydrochloride)

Popular Products