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Ridaforolimus

CAT: 0931-T6334-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T6334-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
572924-54-0
Target
Autophagy, mTOR, Antibacterial
Related Pathways
Autophagy, PI3K/Akt/mTOR signaling, Microbiology/Virology
Purity
0.9855
Bioactivity
Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.
Smiles
[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OP(C)(C)=O)[C@@H](C1)OC
Molecular Formula
C53H84NO14P
Molecular Weight
990.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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