ALK-IN-22

• Target:

  Others|||Apoptosis|||ALK

• Related Pathways:

  Angiogenesis|||Others|||Tyrosine Kinase/Adaptors|||Apoptosis

• Bioactivity:

  ALK-IN-22 (compound I-24) is a potent ALK inhibitor with an IC50 of 2.3 nM for ALK, 3.7 nM for ALKL1196M, and 2.9 nM for ALKG1202R. It down-regulates phosphorylation of ALK and its downstream proteins, inducing apoptosis. ALK-IN-22 is suitable for studying tumors.

• Smiles:

  C(N(C)C)(=O)C=1C=2C(=CC(NC=3N=C(NC4=C(C(NC)=O)C=CC=C4)C(Cl)=CN3)=CC2)NC1C

• Molecular Formula:

  C24H24ClN7O2

• Molecular Weight:

  477.95

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2468219-09-0