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GNF2133 hydrochloride

CAT: 0931-T63040-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63040-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2561414-57-9
Target
DYRK, Others
Related Pathways
Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Others
Bioactivity
GNF2133 hydrochloride is a selective, effective, and orally active DYRK1A inhibitor, able to act on DYRK1A (IC50: 0.0062 μM) and GSK3β (IC50> 50 μM) ; GNF2133 hydrochloride showed good proliferative ability and efficacy in rat and human primary β cells. GNF2133 hydrochloride significantly improved glucose processing ability and increased insulin secretion. GNF2133 hydrochloride has the potential to study type 1 diabetes.
Smiles
Cl.CCN1CCN(CC1)C(=O)Nc1cc(ccn1)-c1cn(C2CCOCC2)c2cnccc12
Molecular Formula
C24H31ClN6O2
Molecular Weight
471
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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