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AT7867

CAT: 0931-T6304-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T6304-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
857531-00-1
Target
Akt, PKA, S6 Kinase
Related Pathways
Tyrosine Kinase/Adaptors, MAPK, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Purity
0.9965
Bioactivity
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 values of 32 nM, 17 nM, 47 nM, 85 nM, and 20 nM, respectively, exhibiting little activity outside the AGC kinase family.
Smiles
Clc1ccc(cc1)C1(CCNCC1)c1ccc(cc1)-c1cn[nH]c1
Molecular Formula
C20H20ClN3
Molecular Weight
337.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

AT-7867

AT7867 is a member of the class of piperidines carrying two aryl substituents (4-chlorophenyl and 4-(pyrazol-4-yl)phenyl) at position 4. It has a role as an antineoplastic agent and an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of piperidines, a member of pyrazoles and a member of monochlorobenzenes.

CAS Number857531-00-1
PubChem CID11175137
IUPAC Name4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine
Molecular FormulaC20H20ClN3
Molecular Weight337.8
XLogP4.3
Topological Polar Surface Area40.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity394
SMILES
C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
InChI
InChI=1S/C20H20ClN3/c21-19-7-5-18(6-8-19)20(9-11-22-12-10-20)17-3-1-15(2-4-17)16-13-23-24-14-16/h1-8,13-14,22H,9-12H2,(H,23,24)
InChIKey
LZMOSYUFVYJEPY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AT-7867
CAS: 857531-00-1
CID: 11175137
Formula: C20H20ClN3
MW: 337.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.8
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass337.1345753
Monoisotopic Mass337.1345753
Topological Polar Surface Area40.7 Ų
Heavy Atom Count24
Formal Charge0
Complexity394
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
401100AT7867

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