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CCT128930 hydrochloride

CAT: 0931-T6303L-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T6303L-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2453324-32-6
Target
Apoptosis, Akt, Autophagy, mTOR, PKA
Related Pathways
Apoptosis, PI3K/Akt/mTOR signaling, Autophagy, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Purity
0.9975
Bioactivity
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM) .
Smiles
Cl.NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12
Molecular Formula
C18H21Cl2N5
Molecular Weight
378.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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MBS3617092-01CCT128930 hydrochloride
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B1763-1CCT128930

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